DC-38-V Chemical Properties

Melting point:

265.5°C

Boiling point:

507.55°C (rough estimate)

Density 

1.2522 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

8.56±0.20(Predicted)

form 

A film

color 

Yellow

DC-38-V Usage And Synthesis

Uses

Gilvocarcin V is the major analogue of a complex of C-glycoside antitumour actives isolated from a Streptomyces sp.. Gilvocarcin V contains a vinyl group in the 8-position, and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. The metabolite displays potent antibacterial, antifungal, antiviral and antitumour activity. Recent research suggests that the gilvocarcins act as photoactivated crosslinkers of DNA to histones.

Uses

Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp.. Gilvocarcin V contains a vinyl group in the 8-position, and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. The metabolite displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research suggests that the gilvocarcins act as photoactivated cross-linkers of DNA to histones.

Uses

Gilvocarcin V is a metabolite that displays potent antibacterial, antifungal and antiviral activity.

storage

+4°C

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