5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide
5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide Basic information
- Product Name:
- 5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide
- Synonyms:
-
- ITCL
- N-(p-Chlorophenyl)-5-benzoylamino-3-methyl-4-isothiazolecarboxamide
- T-15【ITCL】
- 5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide
- 4-Isothiazolecarboxamide, 5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-
- 5-benzamido-N-(4-chlorophenyl)-3-methyl-1,2-thiazole-4-carboxamide
- CAS:
- 51287-57-1
- MF:
- C18H14ClN3O2S
- MW:
- 371.84
- Product Categories:
-
- APIs
- Mol File:
- 51287-57-1.mol
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5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide Chemical Properties
- Boiling point:
- 360.0±42.0 °C(Predicted)
- Density
- 1.440±0.06 g/cm3(Predicted)
- pka
- 11.14±0.70(Predicted)
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5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide Usage And Synthesis
Uses
Denotivir (Vratizolin) is an orally active antiviral agent for herpes simplex virus (HSV) and varicella-zoster virus (VZV). Denotivir inhibits the proliferation of various cancer cells, and exhibits anti-leukemic activity. Denotivir inhibits the generation of TNF-α, IL-1 and IL-6, exhibits immunosuppressive efficacy[1].
References
[1] Machoń Z, et al., Immunotropic activity of vratizolin (ITCL, Denotivir). Pol J Pharmacol. 2001 Jul-Aug;53(4):377-83. PMID:11990084
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