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epidermin

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epidermin Basic information

Product Name:
epidermin
Synonyms:
  • epidermin
  • PubChem ID: 16132391
  • L-Cysteinamide, L-isoleucyl-L-alanyl-D-cysteinyl-L-lysyl-L-phenylalanyl-L-isoleucyl-L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-prolylglycyl-L-cysteinyl-L-alanyl-L-lysyl-(2Z)-2-amino-2-butenoylglycyl-D-cysteinyl-L-phenylalanyl-L-asparaginyl-D-cysteinyl-L-tyrosyl-N-[(1Z)-2-mercaptoethenyl]-, cyc...
  • L-Cysteinamide, L-isoleucyl-L-alanyl-D-cysteinyl-L-lysyl-L-phenylalanyl-L-isoleucyl-L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-prolylglycyl-L-cysteinyl-L-alanyl-L-lysyl-(2Z)-2-amino-2-butenoylglycyl-D-cysteinyl-L-phenylalanyl-L-asparaginyl-D-cysteinyl-L-tyrosyl-N-[(1Z)-2-mercaptoethenyl]-, cyclic (3→7),(8→11),(16→21),(19→21)-tetrakis(thioether)
CAS:
99165-17-0
MF:
C98H141N25O23S4
MW:
2165.59
Mol File:
99165-17-0.mol
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epidermin Chemical Properties

Density 
1.41±0.1 g/cm3(Predicted)
pka
9.89±0.15(Predicted)
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epidermin Usage And Synthesis

Description

Epidermin is defined as a lantibiotic produced by S. epidermidis, which is a thioether amino acid–containing antimicrobial peptide active against various bacteria, contributing to bacterial interference and colonization on human skin.

Synthesis

Solid-phase peptide synthesis of epidermin:epidermin is synthesized in the ribosome via a precursor protein, followed by enzymatic modifications. It was isolated from the culture filtrate of Staphylococcus epidermidis TU 3298 by adsorption on Amberlite XAD-8. The basic heneicosapeptide amide was chromatographed on Sephadex LH-20 and purified to homogeneity via multiplicative counter-current distributions in one acidic and one neutral system.

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