gidazepam
gidazepam Basic information
- Product Name:
- gidazepam
- Synonyms:
-
- gidazepam
- 1H-1,4-Benzodiazepine-1-aceticacid, 7-bromo-2,3-dihydro-2-oxo-5-phenyl-, hydrazide
- Gidasepam
- Hidazepam
- Hydazepam
- 7-Bromo-2,3-Dihydro-2-Oxo-5-Phenyl-1H-1,4-Benzodiazepine-1-Aceticacid Hydrazide
- CAS:
- 129186-29-4
- MF:
- C17H15BrN4O2
- MW:
- 387.236
- EINECS:
- 202-303-5
- Product Categories:
-
- gidazepam
- Mol File:
- 129186-29-4.mol
gidazepam Chemical Properties
- Boiling point:
- 675.6±55.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 12.37±0.37(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C17H15BrN4O2/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)20-9-16(24)22(14)10-15(23)21-19/h1-8H,9-10,19H2,(H,21,23)
- InChIKey
- XLGCMZLSEXRBSG-UHFFFAOYSA-N
- SMILES
- N1(CC(NN)=O)C2=CC=C(Br)C=C2C(C2=CC=CC=C2)=NCC1=O
gidazepam Usage And Synthesis
Uses
Gidazepam is an agonist of GABA receptor channels (GABA RCs).
in vivo
Mice are distributed into 10 groups of five animals each, treated orally with Gidazepam (GDZ, 1 mg/kg); ester 1 (175 mg/kg); ester 2 (20 mg/kg); esters 3 and 4 (200 mg/kg); mixtures of Gidazepam and esters 1-4. All esters of GABA with monoterpenes display antiseizure effects in 3 h after oral administration as evidenced by increasing of inducing clonic-tonic convulsions (DCTC) and tonic extension (DTE) values. Gidazepam (1 mg/kg) is found to protect against seizures with DCTC and DTE values of 250% and 215%, accordingly; whereas co-administration of Gidazepam and esters 5-7 is shown to increase anticonvulsant activity compared with each compound alone[1].
References
[1] N. Ya Golovenko, et al. Pharmacodynamical and Neuroreceptor Analysis of the Permeability of the Blood-Brain Barrier for Derivatives of 1,4-Benzodiazepine. Neurophysiology, Vol. 46, No. 3, June, 2014.
[2] Nesterkina M, et al. Synthesis and Pharmacological Properties of Novel Esters Based on Monocyclic Terpenes and GABA. Pharmaceuticals (Basel). 2016 Jun 13;9(2). pii: E32. DOI:10.3390/ph9020032
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