NOX-6-18 Chemical Properties

Boiling point:

584.4±60.0 °C(Predicted)

Density 

1.366±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

pka

2.50±0.30(Predicted)

form 

Solid

color 

White to off-white

NOX-6-18 Usage And Synthesis

Uses

NOX-6-18 is a highly potent and selective GPR132 antagonist that promotes insulin secretory activity, regulates macrophage reprogramming in pancreatic islets, and reduces weight gain, and may be used as a candidate ingredient for the treatment of diabetes.

Description

NOX-6-18 (GPR132 antagonist 1) is a potent, selective GPR132 antagonist with IC50 of 17 nM. It modulates macrophage reprogramming within pancreatic islets, decreases weight gain, and enhances glucose metabolism in mice fed a high-fat diet.