NOX-6-18
NOX-6-18 Basic information
- Product Name:
- NOX-6-18
- Synonyms:
-
- NOX-6-18
- GPR132 antagonist 1 (NOX-6-18)
- CAS:
- 898211-21-7
- MF:
- C18H17NO5S
- MW:
- 359.4
- Mol File:
- 898211-21-7.mol
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NOX-6-18 Chemical Properties
- Boiling point:
- 584.4±60.0 °C(Predicted)
- Density
- 1.366±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
- pka
- 2.50±0.30(Predicted)
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NOX-6-18 Usage And Synthesis
Uses
NOX-6-18 is a highly potent and selective GPR132 antagonist that promotes insulin secretory activity, regulates macrophage reprogramming in pancreatic islets, and reduces weight gain, and may be used as a candidate ingredient for the treatment of diabetes.
Description
NOX-6-18 (GPR132 antagonist 1) is a potent, selective GPR132 antagonist with IC50 of 17 nM. It modulates macrophage reprogramming within pancreatic islets, decreases weight gain, and enhances glucose metabolism in mice fed a high-fat diet.