5H-indeno[1,2-b]pyridin-5-one oxime
5H-indeno[1,2-b]pyridin-5-one oxime Basic information
- Product Name:
- 5H-indeno[1,2-b]pyridin-5-one oxime
- Synonyms:
-
- 5H-indeno[1,2-b]pyridin-5-one oxime
- Perk Inhibitor III, LDN-0070977
- CAS:
- 65939-03-9
- MF:
- C12H8N2O
- MW:
- 196.2
- Mol File:
- 65939-03-9.mol
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5H-indeno[1,2-b]pyridin-5-one oxime Chemical Properties
- Melting point:
- 247-247.5 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 428.4±27.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 50mg/mL
- pka
- 9.75±0.20(Predicted)
- form
- powder
- color
- off-white
- SMILES
- O/N=C(C1=C2N=CC=C1)/C3=C2C=CC=C3
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5H-indeno[1,2-b]pyridin-5-one oxime Usage And Synthesis
Uses
A cell-permeable tricyclic heterocycle oxime that acts as a reversible and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC50 = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a. Shown to reduce thapsigargin-induced elF2a phosphorylation in mouse embryonic fibroblasts over a wide range. Does not exhibit any cellular toxicity up to 50 µM levels.
A cell-permeable, reversible, and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC₅₀ = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a.
Biological Activity
Cell permeable: yes', 'Primary Target
PERK