FETPPS
FETPPS Basic information
- Product Name:
- FETPPS
- Synonyms:
-
- 5,10,15,20-TETRAKIS(4-SULFONATOPHENYL)-21H,23H-PORPHINE IRON(III) CHLORIDE
- 5,10,15,20-TETRAKIS(4-SULFONATOPHENYL)PORPHYRINATO IRON (III), CHLORIDE
- 5,10,15,20-TETRAKIS-(4-SULFONATOPHENYL)-PORPHYRIN-FE(III) CHLORIDE
- FETPPS
- FE(III) MESO-TETRA(4-SULFONATOPHENYL)PORPHINE CHLORIDE
- FE(III) MESO-TETRA(4-SULFONATOPHENYL)PORPHINE CHLORIDE (ACID FORM)
- Iron(III) meso -tetra(4-sulfonatophenyl)porphine chloride (acid form)
- FeTPPS, peroxynitrite decomposition catalyst and scavenger
- CAS:
- 90384-82-0
- MF:
- C44H25ClFeN4O12S4(-3)
- MW:
- 1021.24
- Product Categories:
-
- Porphyrins
- Mol File:
- Mol File
FETPPS Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Water: 5 mg/ml
- form
- A crystalline solid
- color
- Brown to black
- Water Solubility
- water: soluble
- InChIKey
- HTJVCSCYYTXCSQ-YKKPBKTHSA-J
FETPPS Usage And Synthesis
Description
Peroxynitrite is a highly reactive nitrogen species formed from the reaction of nitric oxide (NO) and superoxide. FeTPPS is a ferric porphyrin complex that causes the decomposition of peroxynitrite by catalytic isomerization to produce nitrate both in vitro and in vivo. The conversion of this reactive nitrogen species to nitrate results in cytoprotection (EC50 = 5 μM). FeTPPS does not complex with NO and does not alter superoxide directly. It is commonly used to elucidate the roles of peroxynitrite in oxidative stress, cell damage, and intracellular signaling.
Uses
FeTPPS is an iron porphyrin complex used as a water-soluble catalyst for oxidations in organic syntheses.
References
[1] XINGMIAO CHEN. Pros and cons of current approaches for detecting peroxynitrite and their applications.[J]. Biomedical Journal, 2014, 37 3: 120-126. DOI: 10.4103/2319-4170.134084
[2] BENJAMIN LAUZIER. A peroxynitrite decomposition catalyst: FeTPPS confers cardioprotection during reperfusion after cardioplegic arrest in a working isolated rat heart model[J]. Fundamental & Clinical Pharmacology, 2007, 21 2: 173-180. DOI: 10.1111/j.1472-8206.2007.00467.x
[3] T P MISKO. Characterization of the cytoprotective action of peroxynitrite decomposition catalysts.[J]. The Journal of Biological Chemistry, 1998, 273 25: 15646-15653. DOI: 10.1074/jbc.273.25.15646
[4] TAUHEED ISHRAT. Role of matrix metalloproteinase activity in the neurovascular protective effects of Angiotensin antagonism.[J]. Stroke Research and Treatment, 2014, 2014: 560491. DOI: 10.1155/2014/560491
[5] JIANHUI LI. Peroxynitrite is a key mediator of the cardioprotection afforded by ischemic postconditioning in vivo.[J]. PLoS ONE, 2013: e70331. DOI: 10.1371/journal.pone.0070331
[6] ATTILA KISS. The role of arginase and rho kinase in cardioprotection from remote ischemic perconditioning in non-diabetic and diabetic rat in vivo.[J]. PLoS ONE, 2014: e104731. DOI: 10.1371/journal.pone.0104731
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