4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE Chemical Properties

Melting point:

86-89°C

Boiling point:

100 °C(Press: 0.001 Torr)

Density 

1.272±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

form 

Powder

pka

5.95±0.20(Predicted)

Appearance

Brown to black Solid

CAS DataBase Reference

2933-29-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

RTECS 

DL6425000

HazardClass 

IRRITANT

HS Code 

2934208090

Toxicity

mouse,LD50,intravenous,72mg/kg (72mg/kg),Acta Pharmaceutica Suecica. Vol. 8, Pg. 49, 1971.

4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE Usage And Synthesis

Synthesis Reference(s)

Tetrahedron, 37, p. 2607, 1981 DOI: 10.1016/S0040-4020(01)98964-1

Synthesis

GENERAL METHODS: A mixture of cyclohexanone (2 mmol), thiourea (3 mmol) and iodine (2 mmol) was reacted by refluxing in ethanol in the presence of 0.03 g of nano-chitosan catalyst. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was petroleum ether to ethyl acetate in 4:1 volume ratio). Upon completion of the reaction, the catalyst was removed by simple filtration. After evaporation to remove the solvent, the crude product was dissolved in boiling water and extracted with ether (3 x 30 mL). Subsequently, the pH of the aqueous phase was adjusted to 8 with ammonia to precipitate the solid product. Finally, pure 2-amino-4,5,6,7-tetrahydrobenzothiazole was obtained by recrystallization from ethanol-water mixed solvent.

References

[1] Catalysis Communications, 2016, vol. 77, p. 108 - 112
[2] Patent: KR2017/23387, 2017, A. Location in patent: Paragraph 0054; 0056; 0057
[3] Chemical and Pharmaceutical Bulletin, 2004, vol. 52, # 5, p. 634 - 637
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 3, p. 718 - 725
[5] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986, vol. 25, p. 966

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