H-GLU-ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL-OH Chemical Properties

Boiling point:

1358.4±65.0 °C(Predicted)

Density 

1.223±0.06 g/cm3(Predicted)

storage temp. 

-20°C

pka

3.32±0.10(Predicted)

form 

lyophilized powder

color 

white

Water Solubility 

water, double-distilled: soluble

Sequence

Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val

H-GLU-ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL-OH Usage And Synthesis

Uses

MART-1 (26-35) (human) is amino acid residue 26 to 35 of MART-1 protein.

Biological Activity

Melanoma-associated antigen recognized by T cells-1 (MART-1) is essential for the functioning of glycoprotein-100 (gp100). Overexpression of the gene has been observed in cutaneous melanoma (CM). In addition, deletion of Mart-1 gene leads to parotid metastatic melanoma.

References

[1] Coulie PG, et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med. 1994 Jul 1;180(1):35-42. DOI:10.1084/jem.180.1.35
[2] Borbulevych OY, et al. Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition. J Mol Biol. 2007 Oct 5;372(5):1123-36. DOI:10.1016/j.jmb.2007.07.025

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