4-BROMO-2-METHOXYBENZOIC ACID Chemical Properties

Melting point:

155-159°C

Boiling point:

318.1±27.0 °C(Predicted)

Density 

1.625±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

3.86±0.10(Predicted)

form 

powder

color 

Off white

InChI

InChI=1S/C8H7BrO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4H,1H3,(H,10,11)

InChIKey

CEZLPETXJOGAKX-UHFFFAOYSA-N

SMILES

C(O)(=O)C1=CC=C(Br)C=C1OC

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25

Safety Statements 

45

RIDADR 

2811

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

2918999090

4-BROMO-2-METHOXYBENZOIC ACID Usage And Synthesis

Chemical Properties

Pale yellow liquid

Uses

4-Bromo-2-methoxybenzoic acid is a nucleophilic reagent that can be used to synthesize other compounds.

Reactions

4-Bromo-2-methoxybenzoic acid reacts with lithium aluminium hydride (LiAlH) and aluminium hydride (AlH) to produce lithium 4-bromo-2-methoxybenzoate and aluminium 4-bromo-2-methoxybenzoate, respectively. These compounds are used in organic synthesis as Grignard reagents for the introduction of methoxy groups.

Synthesis

General procedure for the synthesis of 2-methoxy-4-bromobenzoic acid from 2-hydroxy-4-bromobenzoic acid and iodomethane: 1. in a dry reaction flask, 2-hydroxy-4-bromobenzoic acid (1.2 g, 5.53 mmol) was dissolved in N,N-dimethylformamide (30 mL). 2. Potassium carbonate (2.3 g, 16.59 mmol) and iodomethane (861 μL, 13.83 mmol) were added to the above solution. 3. The reaction mixture was stirred at room temperature for 18 h. 4. 4. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the solvent. 5. The residue was dissolved in ethyl acetate and washed with deionized water. 6. 6. The aqueous layer was separated and back-extracted with ethyl acetate (2×). 7. All organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. 8. After filtration to remove the desiccant, the filtrate was concentrated under vacuum to give 2-methoxy-4-bromobenzoic acid as an orange oil (1.27 g, 94% yield). 9. The product was characterized by 1H NMR (400 MHz, CDCl3) and LRMS APCI: 1H NMR δ 3.88 (s, 1H), 3.90 (s, 3H), 7.11-7.15 (m, 2H), 7.68 (d, 1H); LRMS APCI m/z 245/247 [M + H]+ .

References

[1] Patent: WO2006/100588, 2006, A1. Location in patent: Page/Page column 55-56

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