N,N-Dibenzylethanolamine Chemical Properties

Melting point:

38°C

Boiling point:

206 °C / 15mmHg

Density 

1,06 g/cm³

Flash point:

38 °C

storage temp. 

Sealed in dry,Room Temperature

form 

powder to lump to clear liquid

pka

14.73±0.10(Predicted)

color 

White or Colorless to Light yellow

InChI

InChI=1S/C16H19NO/c18-12-11-17(13-15-7-3-1-4-8-15)14-16-9-5-2-6-10-16/h1-10,18H,11-14H2

InChIKey

WTTWSMJHJFNCQB-UHFFFAOYSA-N

SMILES

C(O)CN(CC1=CC=CC=C1)CC1=CC=CC=C1

CAS DataBase Reference

101-06-4(CAS DataBase Reference)

EPA Substance Registry System

Ethanol, 2-[bis(phenylmethyl)amino]- (101-06-4)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

RIDADR 

UN2735

RTECS 

KJ8125000

HazardClass 

8

HS Code 

2905190098

Toxicity

rat,LDLo,oral,3400mg/kg (3400mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDGASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDSLUNGS, THORAX, OR RESPIRATION: DYSPNEA,National Technical Information Service. Vol. OTS0534870,

N,N-Dibenzylethanolamine Usage And Synthesis

Synthesis

The general procedure for the preparation of N,N-dibenzyl-2-aminoethanol is as follows: 1. dibenzylamine (0.5 g, 2.5 mmol), ethylene carbonate (0.446 g, 5 mmol) and tetraethylammonium iodide (0.215 g, 0.83 mmol) were mixed in a reaction flask at room temperature. 2. The mixture was heated to 140 °C and the reaction was stirred at this temperature for 26 hours to form a suspension. 3. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and subsequently extracted with 0.5 M sodium hydroxide solution (10 mL). 4. The aqueous phase was washed with ethyl acetate and all organic phases were combined. 5. The organic phase was washed twice with saturated brine to remove water-soluble impurities. 6. The organic layer was dried with anhydrous magnesium sulfate and filtered to remove the desiccant. 7. The filtrate was concentrated under reduced pressure to give the crude product. 8. The crude product was purified by rapid chromatography on silica gel using ethyl acetate/hexane (1:2, v/v) as eluent. 9. The target fraction was collected and concentrated under reduced pressure to afford N,N-dibenzyl-2-aminoethanol (0.5 g, 83% yield) as an oil.

References

[1] Patent: WO2008/62006, 2008, A1. Location in patent: Page/Page column 13

N,N-Dibenzylethanolamine(101-06-4)Related Product Information

• N-Methyldiethanolamine
• Monoethanolamine
• Diethanolamine
• N-Benzylethanolamine
• 2-Methylaminoethanol
• N,N'-Diphenylbenzidine
• N,N-dibenzylglycine
• N,N-DIMETHYL-M-PHENYLENEDIAMINE DIHYDROCHLORIDE
• N,N-DIETHYL-O-TOLUIDINE
• N,N-DIMETHYLBUTYRAMIDE
• N,N-diMethyl-2-phenylethylaMine hydrochloride (USAF EL-79)
• N,N-dimethyl-4-vinylaniline
• N,O-dimethyl-N'-nitroisourea
• N,N-DIETHYLSALICYLAMIDE
• N,N-Dimethyl-p-toluidine
• N,N-DIMETHYL-2-FLUOROANILINE
• N,N-dimethyl-m-phenylenediamine
• N,N,3,5-TETRAMETHYLANILINE