[1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol CAS#: 10172-03-9

[1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol Basic information

Product Name:

[1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol

Synonyms:

[1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol
Limacusine
2H-1,24:12,15-Dietheno-6,10-metheno-16H-pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinolin-22-ol, 3,4,4a,5,16a,17,18,19-octahydro-9,21,25-trimethoxy-4,17-dimethyl-, (4aR,16aR)-

CAS:

10172-03-9

MF:

C37H40N2O6

MW:

608.72

Mol File:

10172-03-9.mol

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[1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol Chemical Properties

Melting point:: 235-7°C
Boiling point:: 709.7±60.0 °C(Predicted)
Density: 1.204±0.06 g/cm3(Predicted)
pka: 9.38±0.20(Predicted)

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[1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol Usage And Synthesis

Description

A second bisbenzylisoquinoline base from Limacia cuspidata (Miers.) Hook. f. et Thorn., the alkaloid is separated from the accompanying !imacine by chromato? graphy on a silica column. It crystallizes in colourless prisms from MeOH-Me2 CO and has [α]_D + 110° (CHCI3). One hydroxyl group is present and the alkaloid yields the O-methyl ether as colourless needles, m.p. 210-2° C; [α]_D + 90°, (CHCI3), shown to be identical with N-methyl-dihydroepistephanine B. The structure has been established by chemical interconversions with limacine and cuspidaline (q.v.).

References

Tomita, Furukawa., Tetrahedron Lett., 4293 (I 966)
Structure:
Tomita, Furukawa, Fukagawa., l. Pharm. Soc., lapan, 87,793 (I967)

[1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-olSupplier

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