(4aα)-2-Methylene-5,5,8aβ-trimethyldecalin-1β-methanol Chemical Properties

Melting point:

68-69 °C

Boiling point:

299.3±9.0 °C(Predicted)

Density 

0.95±0.1 g/cm3(Predicted)

pka

14.86±0.10(Predicted)

LogP

4.661 (est)

(4aα)-2-Methylene-5,5,8aβ-trimethyldecalin-1β-methanol Usage And Synthesis

Uses

Albicanol is a sesquiterpenoid with potent antioxidant and antagonistic activities against heavy metal toxicity. Albicanol shows cytotoxicity. Albicanol suppress profenofos (HY-B0832) induced genotoxicity in grass carp hepatocytes[1][2].

Definition

ChEBI: (+)-albicanol is a drimane-type sesquiterpenoid orginally isolated from the liverwort Diplophyllum albicans. It exhibits fish antifeedant, antifungal and antineoplastic activities. It has a role as an antifungal agent, a plant metabolite, an antineoplastic agent, a fungal metabolite, a mammalian metabolite, an antifeedant and a marine metabolite. It is a sesquiterpenoid, a primary alcohol, a homoallylic alcohol and a carbobicyclic compound. It derives from a hydride of a drimane.

References

[1] Zhao DD, et al. Compounds from Dryopteris fragrans (L.) Schott with cytotoxic activity. Molecules. 2014 Mar 18;19(3):3345-55. DOI:10.3390/molecules19033345
[2] Lihui X, et al. Albicanol modulates oxidative stress and the p53 axis to suppress profenofos induced genotoxicity in grass carp hepatocytes. Fish Shellfish Immunol. 2022 Mar;122:325-333. DOI:10.1016/j.fsi.2022.02.002

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