HEXAAMMINECOBALT(III) CHLORIDE Chemical Properties

Melting point:

217 °C(lit.)

Density 

1.71 g/mL at 25 °C(lit.)

storage temp. 

room temp

solubility 

Soluble in ammonia.

form 

Powder

Specific Gravity

1.71

color 

Orange to orange-brown

Water Solubility 

Soluble in ammonia and water.

Merck 

14,4675

Exposure limits

ACGIH: TWA 0.02 mg/m3

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

JXBGZYGSWFSYFI-UHFFFAOYSA-K

CAS DataBase Reference

10534-89-1(CAS DataBase Reference)

EPA Substance Registry System

Cobalt(3+), hexaammine-, trichloride, (OC-6-11)- (10534-89-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

RIDADR 

UN 2811 6.1/PG III

WGK Germany 

3

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

2842908080

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

HEXAAMMINECOBALT(III) CHLORIDE Usage And Synthesis

Chemical Properties

solid

Uses

Hexaamminecobalt(III) chloride is a component of structural biology methods, especially for DNA or RNA, where the positive ions stabilize the tertiary structure of the phosphate backbone, which favors to solve their structure by X-ray crystallography. It serves as an excellent antibacterial and antiviral property.

Uses

As reagent for pyrophosphoric acid, for the estimation of phosphate.

Preparation

Synthesis of hexaamminecobalt(III) chloride
2CoCl2+10NH3+2NH4Cl+H2O2 →2[Co(NH3) 6]Cl3+2H2O
Reaction. Dissolve 2.5 g (10.5 mmol) of cobalt(II) chloride hexahydrate and 1.7 g (32 mmol) of ammonium chloride (about 195% excess) in 15 mL of distilled water. Add 0.5 g of activated charcoal and 23 mL (380 mmol) of concentrated aqueous ammonia (about 624% excess). Cool the reaction mixture to 0 oC in an ice bath. Slowly add 2 mL (19.5 mmol) of 30% hydrogen peroxide (about 271% excess), with stirring – maintain the temperature below 10°C. After the hydrogen peroxide has been added, heat the reaction mixture to 60°C for about 30 minutes. Cool the reaction mixture to 0 oC to cause precipitation of the product.

General Description

Hexammine cobalt(III) is considered an analog of fully solvated magnesium, capable of activating some enzymes that requires magnesium. It is useful in DNA condensation studies.

Purification Methods

It crystallises from warm water (8mL/g) on cooling. [Bjerrum & McReynolds Inorg Synth II 217 1946.]

HEXAAMMINECOBALT(III) CHLORIDE(10534-89-1)Related Product Information

• Cobalt hydroxide
• Sulfite
• COBALT(III) OXIDE BLACK
• Tricobalt tetraoxide
• Cobalt carbonate
• Potassium dichromate
• Cobalt chloride
• HEXAAMMINECOBALT(III) CHLORIDE