ANTIBIOTIC TPU-0037-C
ANTIBIOTIC TPU-0037-C Basic information
- Product Name:
- ANTIBIOTIC TPU-0037-C
- Synonyms:
-
- ANTIBIOTIC TPU-0037-C
- 8-Dehydroxy-30-deMethyllydicaMycin
- TPU-0037C
- 1-Pyrrolidinecarboximidamide, 2-[21-[1-[(2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)carbonyl]-1,2,4a,5,6,7,8,8a-octahydro-5-hydroxy-1,3-dimethyl-2-naphthalenyl]-2,6,10,14,18-pentahydroxy-11,17,19-trimethyl-4,8,12,16-heneicosatetraen-1-yl]-, (+)-
- CAS:
- 485815-61-0
- MF:
- C46H72N4O9
- MW:
- 825.09
- Mol File:
- 485815-61-0.mol
ANTIBIOTIC TPU-0037-C Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
- form
- A film
ANTIBIOTIC TPU-0037-C Usage And Synthesis
Description
TPU-0037C is a metabolite of the marine actinomycete S. platensis that is structurally similar to lydicamycin . It is active against Gram-positive bacteria (MICs = 0.39-3.13 μg/ml), including methicillin-resistant S. aureus strains (MIC = 3.13 μg/ml), but is ineffective against Gram-negative bacteria (MICs = >50 μg/ml).
Uses
Antibiotic TPU-0037-C is an agent with activity against gram-positive bacteria.
Uses
TPU-0037C, a close structural analogue of lydicamycin, has been shown to be highly active against MRSA. TPU-0037C is also closely related to BN 4515N which was isolated from a strain of Microtetraspora as a neuritogenic agent.
References
[1] TAMOTSU FURUMAI. TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598.[J]. Journal of Antibiotics, 2002, 55 10: 873-880. DOI: 10.7164/antibiotics.55.873
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