1,7-Bis-boc-1,4,7-triazaheptane Chemical Properties

Melting point:

68-70°C

Boiling point:

440.5±30.0 °C(Predicted)

Density 

1.035±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

pka

12.28±0.46(Predicted)

form 

Solid

color 

White to Off-White

Safety Information

Safety Statements 

24/25

HS Code 

29225090

1,7-Bis-boc-1,4,7-triazaheptane Usage And Synthesis

Description

1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE contains two Boc protecting groups which can be removed under acidic conditions. The remaining free amines can further react with carbonyl moieties.

Chemical Properties

1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE is white powder

Uses

1,7-BIS-BOC-1,4,7-TRIAZAHEPTANE is used in the preparation of bifunctional chelators that have been then applied to the synthesis of monoclonal antibody conjugates for tumor targeting.

in vitro

1,7-Bis-Boc-1,4,7-triazaheptane is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

1,7-Bis-boc-1,4,7-triazaheptane(117499-16-8)Related Product Information

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