1-Phenylpyrazole-4-boronic acid Chemical Properties

Boiling point:

393.1±34.0 °C(Predicted)

Density 

1.20±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

7.44±0.10(Predicted)

Appearance

White to yellow Solid

Safety Information

HS Code 

2933199090

1-Phenylpyrazole-4-boronic acid Usage And Synthesis

Definition

ChEBI: (1-Phenyl-1H-pyrazol-4-yl)boronic acid is a ring assembly and a member of pyrazoles.

Synthesis

General procedure for the synthesis of 1-phenyl-1H-pyrazole-4-boronic acid pinacol ester from 1-phenyl-1H-pyrazole-4-boronic acid pinacol ester: To a solution of 1-phenyl-1H-pyrazole-4-boronic acid pinacol ester (0.6 g, 3.1 mmol) in acetone/water (30 mL, v/v = 1:1) was added sodium periodate (NaIO4, 2.0 g, 9.3 mmol) and ammonium acetate (NH4OAc, 0.54 g, 7.1 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated to give a residue. The residue was purified by column chromatography (eluent: methanol/dichloromethane = 1:5) to afford the target product 1-phenyl-1H-pyrazole-4-boronic acid (0.3 g, 89% yield) as a light yellow solid. Mass spectrometry (MS) analysis showed a molecular ion peak (m/z) of 189 ([M+H]+).

References

[1] Patent: WO2009/155527, 2009, A2. Location in patent: Page/Page column 134-135

1-Phenylpyrazole-4-boronic acid(1201643-70-0)Related Product Information

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