ALA-LEU-CYS-ASN-CYS-ASN-ARG-ILE-ILE-ILE-PRO-HIS-GLN-CYS-TRP-LYS-LYS-CYS-GLY-LYS-LYS-NH2 [DISULFIDE BRIDGES 3-14, 5-18] TRIFLUOROACETATE SALT Chemical Properties

storage temp. 

−20°C

solubility 

Water: soluble

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

ALA-LEU-CYS-ASN-CYS-ASN-ARG-ILE-ILE-ILE-PRO-HIS-GLN-CYS-TRP-LYS-LYS-CYS-GLY-LYS-LYS-NH2 [DISULFIDE BRIDGES 3-14, 5-18] TRIFLUOROACETATE SALT Usage And Synthesis

Description

Tertiapin Q is a peptide derivative of the honeybee venom peptide and inhibitor of inwardly rectifying potassium (Kir) channels, tertiapin.1 It inhibits heteromultimeric potassium channels composed of G protein-activated inward rectifier potassium channel 1 (GIRK1) and GIRK4, also known as Kir3.1 and Kir3.4, respectively, as well as the inward-rectifier potassium channel 1 (Kir1.1; Kis = 13.3 and 1.3 nM, respectively).2 Tertiapin Q inhibits voltage-stimulated hyperpolarization and increases action potential duration in mouse dorsal root ganglion neurons in a concentration-dependent manner.3 It inhibits BK-type potassium channels in Xenopus oocytes expressing the human BK channel α subunit (IC50 = 5.8 nM).WARNING This product is not for human or veterinary use.

References

[1] WEILI JIN. Mechanisms of Inward-Rectifier K+ Channel Inhibition by Tertiapin-Q†[J]. Biochemistry Biochemistry, 1999, 38 43: 14294-14301. DOI: 10.1021/bi991206j
[2] WEILI JIN  Zhe L. Synthesis of a Stable Form of Tertiapin: A High-Affinity Inhibitor for Inward-Rectifier K+ Channels†[J]. Biochemistry Biochemistry, 1999, 38 43: 14286-14293. DOI: 10.1021/bi991205r
[3] REFIK KANJHAN. Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner.[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 314 3: 1353-1361. DOI: 10.1124/jpet.105.085928