AP-III-a4
AP-III-a4 Basic information
- Product Name:
- AP-III-a4
- Synonyms:
-
- AP-III-a4
- ENOblock (AP-III-a4)
- AP-III-A4 Benzeneacetamide, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]-
- N-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]benzeneacetamide
- AP-III-a4(ENOblock), >98%
- ENOBLOCK
- CS-1077
- ENOBLOCK HYDROCHLORIDE
- CAS:
- 1177827-73-4
- MF:
- C31H43FN8O3
- MW:
- 594.72
- Mol File:
- 1177827-73-4.mol
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AP-III-a4 Chemical Properties
- Density
- 1.250±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 15.25±0.46(Predicted)
- color
- Off-white to light yellow
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AP-III-a4 Usage And Synthesis
Uses
AP-III-a4 (ENOblock) is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM. AP-III-a4 can be used for the research of cancer and diabetic[1].
in vivo
AP-III-a4 (ENOblock) (10 μM; 96 h) inhibits cancer cell metastasis and suppresses the gluconeogenesis regulator PEPCK in zebrafish[1].
| Animal Model: | The zebrafish cancer cell HCT116 xenograft model[1] |
| Dosage: | 10 μM |
| Administration: | 96 h |
| Result: | Reduced cancer cell dissemination. Inhibited PEPCK expression and induced glucose uptake. Inhibited adipogenesis and foam cell formation. |
References
[1] Da-Woon Jung, et al. A Unique Small Molecule Inhibitor of Enolase Clarifies Its Role in Fundamental Biological Processes.ACS Chem. Biol., 2013, 8 (6), pp 1271–1282 DOI:10.1021/cb300687k
AP-III-a4Supplier
Shanghai Boyle Chemical Co., Ltd.
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