9ALPHA,11ALPHA-DIHYDROXY-15-OXO-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC ACID Chemical Properties

solubility 

DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a)

9ALPHA,11ALPHA-DIHYDROXY-15-OXO-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC ACID Usage And Synthesis

Description

tetranor-PGFM is the major urinary metabolite of PGF_2α. Normal healthy females excrete 7-13 μg of tetranor-PGFM per day compared to 11-59 μg/24 hours for healthy males. In pregnant females, tetranor-PGFM levels in the urine are 2 to 5-fold higher and diminish to pre-pregnancy levels soon after labor.

Uses

tetranor-PGFM is the major urinary metabolite of Dinoprost (HY-12956)[1].

Definition

ChEBI: 2,3,4,5-tetranor-prostaglandin FM is a prostanoid that is prostaglandin E2-UM in which the oxo group at position 9 has been reduced to the corresponding alcohol (alpha-configuration). It has a role as a metabolite. It is a prostanoid, an oxo dicarboxylic acid, a secondary alcohol and a ketone.

References

[1] Granstr?m E, et al. The structure of a urinary metabolite of prostaglandin F2a in man. J Am Chem Soc. 1969 Jun 4;91(12):3398-400. DOI:10.1021/ja01040a067

9ALPHA,11ALPHA-DIHYDROXY-15-OXO-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC ACID(23109-94-6)Related Product Information

• 9ALPHA,11ALPHA-DIHYDROXY-15-OXO-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC ACID
• HEXADECANEDIOIC ACID
• 8-OXOTRIDECANOIC ACID
• 1,11-Undecanedicarboxylic acid