GC376
GC376 Basic information
- Product Name:
- GC376
- Synonyms:
-
- GC376
- GPC376
- 376
- GC376 sodium
- 3 alpha, 7 alpha-dyhydroxy-6-ethidene- cholanic acid
- Sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate
- (βS)-α-Hydroxy-β-[[(2S)-4-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-2-oxo-3-pyrrolidinepropanesulfonic acid sodium salt
- GC376 (sodium salt)
- CAS:
- 1416992-39-6
- MF:
- C21H32N3NaO8S
- MW:
- 509.55
- Mol File:
- 1416992-39-6.mol
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GC376 Chemical Properties
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMF: 10 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
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GC376 Usage And Synthesis
Description
GC376 is an inhibitor of the main protease Mpro (3CLpro) in coronaviruses as well as picornaviruses. This broad-spectrum antiviral compound has been used as investigational veterinary drug for treatment of feline infectious peritonitis virus (FIPV) infections. Recent studies also showed that GC376 inhibits the main protease Mpro (3CLpro) from SARS-CoV-2 with IC50 of 0.03 μM and EC50 of 3.37 μM.
Uses
GC 376 sodium is a potential small molecule inhibitor which may be able to reduce the viral load of SARS-CoV-2 3CLpro.
GC376Supplier
Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd. Gold
- Tel
- 13771642864
- snhuyu_2008@126.com
Nanjing Xinmeihe Pharmaceutical Co., Ltd. Gold
- Tel
- 025-57672321 13739186949
- 2548785915@qq.com
TargetMol Chemicals Inc. Gold
- Tel
- 021-33632979 15002134094
- marketing@targetmol.com
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Chemvon Biotechnology Co., Ltd
- Tel
- 021-50790412
- info@chemvon.com