4-Imidazolidinone, 1-ethyl-3-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5,5-dimethyl-2-thioxo- Chemical Properties

Boiling point:

601.6±65.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 250 mg/mL (588.84 mM)

form 

Solid

pka

12.18±0.30(Predicted)

color 

White to off-white

4-Imidazolidinone, 1-ethyl-3-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5,5-dimethyl-2-thioxo- Usage And Synthesis

Uses

5-LOX-IN-4 is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2, table 4, compound example 4.10.

IC 50

5-Lipoxygenase

References

[1] Wauwe V, et al. 5-Lipoxygenase-inhibiting 4-(4-phenyl-1-piperazinyl)phenols and their preparation and pharmaceutical compositions. EP0331232A2