Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt
Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt Basic information
- Product Name:
- Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt
- Synonyms:
-
- Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt
- Digeranyl bisphosphonate
- Digeranyl bisphophonate
- DGBP
- CAS:
- 878143-03-4
- MF:
- C21H39NaO6P2
- MW:
- 472.47
- Mol File:
- 878143-03-4.mol
Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt Chemical Properties
- storage temp.
- Store at -20°C, protect from light, stored under nitrogen
- solubility
- DMSO : 2 mg/mL (3.73 mM; Need ultrasonic)|
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water : 2 mg/mL (3.73 mM; Need ultrasonic)
Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt Usage And Synthesis
Uses
Digeranyl bisphosphonate (DGBP) is a potent geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which inhibits geranylgeranylation of Rac1.
in vivo
To further evaluate the effect of Digeranyl bisphosphonate (DGBP; 0.2 mg/kg/day) in protecting mice from chrysotile-induced pulmonary fibrosis, the mice are administered vehicle or Digeranyl bisphosphonate subcutaneously in osmotic pumps, and exposed to saline or chrysotile the following day. Mice exposed to saline have normal lung architecture with vehicle and Digeranyl bisphosphonate treatment. Chrysotile-exposed mice that receive vehicle have significant architectural changes in their lung parenchyma and large amounts of collagen deposition, whereas the lungs of the Digeranyl bisphosphonate -treated mice are essentially normal. To investigate the effect of Digeranyl bisphosphonate in Bleomycin-induced fibrosis, osmotic pumps containing either vehicle or Digeranyl bisphosphonate are implanted subcutaneously in WT mice. Mice are exposed to saline or Bleomycin the following day. Digeranyl bisphophonate (0.2 mg/kg/day)-treated mice show significantly less hydroxyproline compared to vehicle-treated mice exposed to Bleomycin[1].
References
[1] Osborn-Heaford HL, et al. Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis. Free Radic Biol Med. 2015 Sep;86:47-56. DOI:10.1016/j.freeradbiomed.2015.04.031
Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium saltSupplier
- Tel
- 021-58955995
- sales@medchemexpress.cn
- Tel
- 15911056312
- liming@bio-fount.com
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Tel
- 18818260767
- sales@chemegen.com
- Tel
- 18569809817
- 2208093734@qq.com