ZSET-845
ZSET-845 Basic information
- Product Name:
- ZSET-845
- Synonyms:
-
- ZSET-845
- Imidazo[1,2-a]pyridin-2(3H)-one, 3,3-bis(phenylmethyl)-
- ZSET 845,ZSET845
- CAS:
- 324077-62-5
- MF:
- C21H18N2O
- MW:
- 314.38
- Mol File:
- 324077-62-5.mol
ZSET-845 Chemical Properties
- Boiling point:
- 466.5±28.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 3.57±0.40(Predicted)
ZSET-845 Usage And Synthesis
Uses
ZSET-845 is a cognitive enhancer which enhances choline acetyltransferase activity in the hippocampus in the rat.
in vivo
Treatment with ZSET-845 at the dose of 0.01, 0.1 and 1 mg/kg significantly ameliorates impaired performance caused by scopolamine. Oral administration of ZSET-845 causes an increase in ChAT activity in the hippocampus. In the hippocampus, ZSET-845 (0.01, 0.1 or 1 mg/kg) significantly increases ChAT activity (112%, 113.8% or 108.7%, respectively) compared with matched vehicle-injected control rats[1]. Oral administration of ZSET845 at a dose of 1 or 10 mg/kg ameliorates learning impairment in passive avoidance task and enhanced ChAT activity in the basal forebrain, medial septum and hippocampus, and increases in the number of ChAT-immunoreactive cells in the medial septum in Ab-treated rats to the levels of vehicle-injected control rats[2].
References
[1] Yamaguchi Y, et al. Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat. Jpn J Pharmacol. 2001 Nov;87(3):240-4. DOI:10.1254/jjp.87.240
[2] Yamaguchi Y, et al. Antiamnesic effects of azaindolizinone derivative ZSET845 on impaired learning and decreased ChAT activity induced by amyloid-beta 25-35 in the rat. Brain Res. 2002 Aug 2;945(2):259-65. DOI:10.1016/s0006-8993(02)02816-0
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