3'-O-DMT-T-TNA
3'-O-DMT-T-TNA Basic information
- Product Name:
- 3'-O-DMT-T-TNA
- Synonyms:
-
- 3'-O-DMT-T-TNA
- 1-(3'-O-[4,4'-dimethoxytrityl]-alpha-L-threofuranosyl)-thymine
- 1-(3’-O-[4,4’-dimethoxytrityl]-α-L-threofuranosyl)-thymine
- 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,3R,4S)-4-[bis(4-methoxyphenyl)phenylmethoxy]tetrahydro-3-hydroxy-2-furanyl]-5-methyl-
- 1-(3’-O-[4,4’-dimethoxytrityl]-alpha-L-threofuranosyl)-thymine
- CAS:
- 325683-89-4
- MF:
- C30H30N2O7
- MW:
- 530.58
- Mol File:
- 325683-89-4.mol
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3'-O-DMT-T-TNA Chemical Properties
- Density
- 1.35±0.1 g/cm3(Predicted)
- pka
- 9.55±0.10(Predicted)
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3'-O-DMT-T-TNA Usage And Synthesis
Uses
1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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