MRT-92
MRT-92 Basic information
- Product Name:
- MRT-92
- Synonyms:
-
- MRT-92
- Benzamide, N-[imino[[4-methyl-3-[[4-(2-phenylethyl)benzoyl]amino]phenyl]amino]methyl]-3,4,5-trimethoxy-
- CAS:
- 1428315-82-5
- MF:
- C33H34N4O5
- MW:
- 566.65
- Mol File:
- 1428315-82-5.mol
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MRT-92 Chemical Properties
- Density
- 1.20±0.1 g/cm3(Predicted)
- pka
- 10.29±0.46(Predicted)
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MRT-92 Usage And Synthesis
Uses
MRT-92 is a Smoothened (Smo) antagonist (Ki=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC50=0.4 nM). MRT-92 can be used in the study of cerebellar glioma[1].
References
[1] Hoch, et al. "MRT-92 inhibits Hedgehog signaling by blocking overlap** binding sites in the transmembrane domain of the Smoothened receptor." The FASEB Journal 29.5 (2015): 1817. DOI:10.1096/fj.14-267849