ARS-1323 Chemical Properties

Boiling point:

614.7±55.0 °C(Predicted)

Density 

1.434±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : ≥ 125 mg/mL (290.13 mM)

form 

Solid

pka

6.03±0.35(Predicted)

color 

White to off-white

ARS-1323 Usage And Synthesis

Uses

ARS-1620, is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.

Definition

ChEBI: ARS-1620 is a qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. It has a role as an inhibitor, an antiviral agent and an antineoplastic agent.