2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Chemical Properties

Boiling point:

606.0±50.0 °C(Predicted)

Density 

1.502±0.06 g/cm3(Predicted)

storage temp. 

+2C to +8C

solubility 

DMSO: 100mg/mL
methanol: soluble

form 

Yellow solid

pka

3.62±0.10(Predicted)

color 

yellow

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Usage And Synthesis

General Description

A cell-permeable, specific DNA methyltransferases inhibitor (IC₅₀ = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.

Biochem/physiol Actions

Cell permeable: yes