ICA Chemical Properties

Boiling point:

466.4±48.0 °C(Predicted)

Density 

1.339±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : ≥ 49.5 mg/mL (194.64 mM)

pka

3.20±0.10(Predicted)

form 

Solid

color 

Light brown to brown

ICA Usage And Synthesis

Uses

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 μM.

References

[1] Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93. DOI:10.1016/j.ejmech.2015.08.013
[2] Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76. DOI:10.1097/FJC.0000000000000259