6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE Chemical Properties

Melting point:

130-131 °C(Solv: ethanol (64-17-5); water (7732-18-5))

Boiling point:

388.3±24.0 °C(Predicted)

Density 

1.100±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

Solid

pka

4.32±0.40(Predicted)

color 

Light yellow to yellow

6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE Usage And Synthesis

Description

Acrylodan is a sulfhydryl-reactive fluorescent probe for protein structural studies.

Uses

Acrylodan, reacted with thiols, is sensitive to the local environmental dipolarity and dynamics within the binding pocket surrounding Cys34[1][2].

References

[1] Sarah F Stuart, et al. A two-step mechanism for the folding of actin by the yeast cytosolic chaperonin. J Biol Chem. 2011 Jan 7;286(1):178-84. DOI:10.1074/jbc.M110.166256
[2] K Flora, et al. Unfolding of acrylodan-labeled human serum albumin probed by steady-state and time-resolved fluorescence methods. Biophys J. 1998 Aug;75(2):1084-96. DOI:10.1016/S0006-3495(98)77598-8

6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE(86636-92-2)Related Product Information

• 6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE (ACRYLODAN)
• AKOS 92267
• AKOS 92356
• AKOS 91800
• AKOS 91799
• 6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE
• CASPASE-1 SUBSTRATE XV, CELL-PERMEABLE, FLUOROGENIC
• AKOS 92360