4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one Chemical Properties

Boiling point:

884.7±75.0 °C(Predicted)

Density 

1.44±0.1 g/cm3(Predicted)

pka

14.72±0.20(Predicted)

4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one Usage And Synthesis

Uses

rel-Hydroxy Itraconazole is a relative stereoisomer of Hydroxy Itraconazole. Hydroxy Itraconazole is the major active metabolite of the antifungal compound Itraconazole (HY-17514)[1].

References

[1] Breadmore MC, et al. Determination of itraconazole and hydroxyitraconazole in human serum and plasma by micellar electrokinetic chromatography. J Chromatogr A. 2003 Oct 3;1014(1-2):57-70. DOI:10.1016/s0021-9673(03)00573-9

4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one(207970-87-4)Related Product Information

• N-Desalkyl Itraconazole
• Itraconazole Impurity
• Itraconazole Impurity 21
• Itraconazole Impurity 34
• Itraconazole Impurity
• 2-(2,4-DICHLOROPHENYL)-2-(1,2,4-TRIAZOL-1-YL METHYL)-1,3-DIOXALANE-4-YL METHYL METHANE SULFONATE
• trans-[2-BroMoMethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]Methyl Benzoate
• Itraconazole Impurity 24
• KETO ITRACONAZOLE
• Itraconazole Impurity 12
• 3H-1,2,4-Triazol-3-one, 4-[4-[7-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]-1,2,3,5-tetrahydro-4H-1,4-benzodiazepin-4-yl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel-
• Itraconazole Impurity 24
• cis-2-(2,4-Dichlorophenyl)-2-(4H-1,2,4-triazol-4-ylmethyl)-1,3-dioxolane-4-methanol
• Itraconazole Impurity 15
• Itraconazole Impurity 25
• Cis -Tosylate