3-HYDROXY-2,2-DIMETHOXY-PROPANOIC ACID 3-PHOSPHATE TRI(CYCLOHEXYLAMMONIUM) SALT Chemical Properties

Boiling point:

432.4±47.0 °C(Predicted)

Density 

1.930

storage temp. 

−20°C

pka

1.58±0.10(Predicted)

Safety Information

Hazard Codes 

Xn

Risk Statements 

21/22

Safety Statements 

36/37

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

3-HYDROXY-2,2-DIMETHOXY-PROPANOIC ACID 3-PHOSPHATE TRI(CYCLOHEXYLAMMONIUM) SALT Usage And Synthesis

Uses

3-Hydroxy-2,2-dimethoxy-propanoic Acid-3-phosphatetri(cyclohexylammonium) Salt is used in the preparation of mTORC1 signaling agents that activates ATF.

Definition

ChEBI: A carboxyalkyl phosphate that is pyruvic acid substituted at position 3 by a 3-phosphonooxy group.

Biological Activity

L-Serine may be derived from four possible sources: dietary intake, biosynthesis from the glycolytic intermediate 3-phosphoglycerate, from glycine, and by protein and phospholipid degradation. In the biosynthetic pathway, the glycolytic intermediate 3-phosphoglycerate is converted into phosphohydroxy-pyruvate, in a reaction catalyzed by 3-phosphoglycerate dehydrogenase (3- PGDH; EC 1.1.1.95). Phosphohydroxypyruvate is metabolized to phosphoserine by phosphohydroxypyruvate aminotransferase (EC 2.6.1.52) and, finally, phosphoserine is converted into L-serine by phosphoserine phosphatase (PSP; EC 3.1.3.3). In liver tissue, the serine biosynthetic pathway is regulated in response to dietary and hormonal changes. Of the three synthetic enzymes, the properties of 3-PGDH and PSP are the best documented. Hormonal factors such as glucagon and corticosteroids also influence 3-PGDH and PSP activities in interactions dependent upon the diet. L-serine plays a central role in cellular proliferation. L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. It has long been recognized that, in cell cultures, L-serine is a conditional essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization. In recent years, L-serine and the products of its metabolism have been recognized not only to be essential for cell proliferation, but also to be necessary for specific functions in the central nervous system. The findings of altered levels of serine and glycine in patients with psychiatric disorders and the severe neurological abnormalities in patients with defects of L-serine synthesis underscore the importance of L-serine in brain development and function; e.g. Alzheimerμs disease, schizophrenia, heart failure, and juvenile myoclonic epilepsy.

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