19-O-Acetylchaetoglobosin A Chemical Properties

Boiling point:

781.3±60.0 °C(Predicted)

Density 

1.29±0.1 g/cm3(Predicted)

storage temp. 

-20°C

form 

A solid

pka

17.32±0.30(Predicted)

19-O-Acetylchaetoglobosin A Usage And Synthesis

Biological Activity

19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities.1,2 It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.2 19-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1

References

1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, K., Natori, S., et al.Structure-activity relationship of thirty-nine cytochalasans observed in the effects on cellular structures and cellular events and on actin polymerization in vitroJ. Pharmacobiodyn.8(11)906-916(1985)