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19-O-Acetylchaetoglobosin A

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19-O-Acetylchaetoglobosin A Basic information

Product Name:
19-O-Acetylchaetoglobosin A
Synonyms:
  • 19-O-Acetylchaetoglobosin A
  • 12H-Cyclotridec[d]oxireno[f]isoindole-8,11,12-trione, 7-(acetyloxy)-3,4,7,13,14,14a,15,15a,16a,16b-decahydro-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-, (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)- (9CI)
  • Chaetoglobosin A Acetate
  • (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-7-(acetyloxy)-3,4,7,13,14,14a,15,15a,16a,16b-decahydro-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-12H-cyclotridec[d]oxireno[f]isoindole-8,11,12-trione
  • Acetylchaetoglobosin A, 19-O-
CAS:
50939-69-0
MF:
C34H38N2O6
MW:
570.68
Mol File:
50939-69-0.mol
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19-O-Acetylchaetoglobosin A Chemical Properties

Boiling point:
781.3±60.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
-20°C
form 
A solid
pka
17.32±0.30(Predicted)
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19-O-Acetylchaetoglobosin A Usage And Synthesis

Biological Activity

19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities.1,2 It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.2 19-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1

References

1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, K., Natori, S., et al.Structure-activity relationship of thirty-nine cytochalasans observed in the effects on cellular structures and cellular events and on actin polymerization in vitroJ. Pharmacobiodyn.8(11)906-916(1985)

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