1,5-Dimethylpyrazole Chemical Properties

Melting point:

82.75°C (estimate)

Boiling point:

158°C(lit.)

Density 

0.9813

refractive index 

1.4790 to 1.4830

storage temp. 

Sealed in dry,Room Temperature

pka

2.83±0.10(Predicted)

form 

liquid

color 

Clear

λmax

217nm(EtOH)(lit.)

CAS DataBase Reference

694-31-5(CAS DataBase Reference)

NIST Chemistry Reference

1,5-Dimethylpyrazole(694-31-5)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25

Safety Statements 

45

RIDADR 

UN 1993 3/PG III

HazardClass 

IRRITANT

PackingGroup 

III

HS Code 

2933199090

1,5-Dimethylpyrazole Usage And Synthesis

Uses

1,5-Dimethylpyrazole is widely used in food, health products, cosmetics and other fields.

Synthesis

Researchers have reported the alkylation of 3(5)-methylpyrazole with methyl iodide and dimethylcarbonate. However, these methods employ expensive reagents and low yields, and the technology is complex. For practical purposes, a better option is to use dimethylsulfate (DMS) in an alkaline medium as the alkylation agent. Isomers of 1,3-dimethylpyrazole and 1,5-dimethylpyrazole are obtained in a 20% aqueous solution of NaOH at 70°C. The yield of the 60 : 40 mixture of the isomers1,3-dimethylpyrazole and 1,5-dimethylpyrazole is 85%[1].

References

[1] V. V. Rusak. “Extracting 1,3-dimethylpyrazole and 1,5-dimethylpyrazole from binary industrial mixtures.” Coke and Chemistry 58 7 (2015): 275–278.

1,5-Dimethylpyrazole(694-31-5)Related Product Information

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• ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE
• 4-ACETYL-5-METHYL-1-PHENYLPYRAZOLE
• 2-[1-METHYL-5-(TRIFLUOROMETHYL)PYRAZOL-3-YL]-THIOPHENE-5-SULFONYL CHLORIDE
• 3,5-DIMETHYL-1-PHENYLPYRAZOLE
• 3,5-DIMETHYLPYRAZOLE-1-CARBOXAMIDE,3,5-DIMETHYLPYRAZOLE-1-CARBOXYAMIDE
• 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
• 5-[(4-BROMO-3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHYL]-1,3,4-OXADIAZOLE-2-THIOL
• 1,3,5-Trimethylpyrazole
• 2-[1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOL-5-YL]-THIOPHENE-5-CARBOXALDEHYDE
• 1-CYANOACETYL-3,5-DIMETHYLPYRAZOLE
• 4-Bromo-1,3,5-trimethyl-1H-pyrazole
• 3,5-DIMETHYLPYRAZOLE-1-CARBINOL,1-HYDROXYMETHYL-3,5-DIMETHYLPYRAZOLE,3,5-DIMETHYLPYRAZOLE-1-METHANOL