CDDO-2-P-Im
CDDO-2-P-Im Basic information
- Product Name:
- CDDO-2-P-Im
- Synonyms:
-
- CDDO-2-P-Im
- CPD1589
- CPDB1589
- CDDO-3P-Imidazolide
- Oleana-1,9(11)-diene-2-carbonitrile, 3,12,28-trioxo-28-[4-(3-pyridinyl)-1H-imidazol-1-yl]-
- CDDO 3P Im,CDDO3PIm
- CDDO-3P-Im, 10 mM in DMSO
- CAS:
- 1883650-95-0
- MF:
- C39H46N4O3
- MW:
- 618.81
- Mol File:
- 1883650-95-0.mol
CDDO-2-P-Im Chemical Properties
- Boiling point:
- 771.1±70.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 250 mg/mL (404.00 mM)
- form
- Solid
- pka
- 3.34±0.12(Predicted)
- color
- White to off-white
CDDO-2-P-Im Usage And Synthesis
Uses
CDDO-3P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-3P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model[1]. CDDO-3P-Im is a orally active necroptosis inhibitor that can be used for the research of ischemia/reperfusion (I/R)[2].
in vivo
CDDO-3P-Im is more stable than CDDO-Im in pharmacokinetic studies[1].
CDDO-3P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo[1].
CDDO-3P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice[1].
| Animal Model: | Seven week-old female A/J mice[1] |
| Dosage: | 50 mg/kg, 200 mg/kg |
| Administration: | Diet; for 16 weeks |
| Result: | Decreased the number, the size and the severity of tumors. |
References
[1] Cao M , et al. Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention. Pharmacol Res. 2015 Oct;100:135-47. DOI:10.1016/j.phrs.2015.07.024
[2] Yuanyuan Wang, et al. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors. Eur J Med Chem. 2020 Nov 21;113030. DOI:10.1016/j.ejmech.2020.113030
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