2-Benzofurancarboxylic acid ethyl ester Chemical Properties

Melting point:

166-170℃

Boiling point:

105°/0.1mm

Density 

1.1656

refractive index 

1.5640 (estimate)

Flash point:

>110℃

storage temp. 

2-8°C

CAS DataBase Reference

3199-61-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2932190090

2-Benzofurancarboxylic acid ethyl ester Usage And Synthesis

Uses

Ethyl Coumarilate has been used as a reactant for the preparation of benzofuropyridines that have a high affinity for the α2-adrenoceptor.

Preparation

Synthesis of ethyl benzofuran-2-carboxylate: Salicylaldehyde (20.0 mL, 0.164 mol) and diethyl bromomalonate (40.0 mL, 0.168 mol) in ethyl methyl ketone (40.0 mL, 0.555 mol) was treated with anhydrous potassium carbonate (20.0 g,0.869 mol). The reaction mixture was refluxed for 18 h on steam bath. Ethyl methyl ketone was distilled off under reduced pressure and the residue formed was dissolved in 400 mL of water and cooled in an ice-bath. It was acidified with dil H2SO4. The product formed was extracted with 25 mL portion of solvent ether twice and the extract was washed with sodium bicarbonate solution. It was dried over calcium chloride. Solvent was removed and the residue ethyl benzofuran-2-carboxylate was dried.

Synthesis Reference(s)

Tetrahedron Letters, 27, p. 6315, 1986 DOI: 10.1016/S0040-4039(00)87796-5

2-Benzofurancarboxylic acid ethyl ester(3199-61-9)Related Product Information

• ETHYL 7-METHOXYBENZOFURAN-2-CARBOXYLATE
• ETHYL 3-AMINOBENZOFURAN-2-CARBOXYLATE
• 5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
• 2-Benzofurancarboxylic acid ethyl ester
• triamcinolone furetonide
• ETHYL 5-NITROBENZOFURAN-2-CARBOXYLATE
• 3-METHYLBENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
• 3-AMINO-5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
• 7-CHLORO-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
• 5-METHOXYBENZOFURAN-2-CARBOXYLIC ACID, ETHYL ESTER
• ETHYL NAPHTHO[2,1-B]FURAN-2-CARBOXYLATE
• 5-METHOXY-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
• 3-AMINO-5-BROMO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
• ETHYL 4-HYDROXY-3-METHYLBENZOFURAN-2-CARBOXYLATE
• ETHYL(5-BROMOBENZOFURAN)-2-CARBOXYLATE
• 5-Hydroxy-2-methyl-3-benzofurancarboxylic acid ethyl ester
• 7-bromo-2-Benzofurancarboxylic acid ethyl ester
• 3-METHYL-5-(3-OXO-BUTYL)-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER