E-64C Chemical Properties

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

≥31.4 mg/mL in DMSO; insoluble in H2O; ≥111.8 mg/mL in EtOH

form 

White to off-white solid

InChIKey

SCMSYZJDIQPSDI-SRVKXCTJSA-N

Safety Information

WGK Germany 

3

RTECS 

RR0404200

HS Code 

29241990

MSDS

• Language:English Provider:SigmaAldrich

E-64C Usage And Synthesis

Description

E-64c is an active metabolite of the protease inhibitor E-64d . E-64c inhibits the cysteine proteases cathepsin B, cathepsin H, and papain but not the serine proteases trypsin, chymotrypsin, or elastase. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease when used at concentrations ranging from 0.1 to 1 mg/ml. E-64c reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) surface glycoprotein, also known as the spike glycoprotein, in a concentration-dependent manner.

Uses

E-64c is a cysteine protease inhibitor used for detecting autophagy in plants.

Definition

ChEBI: E-64c is a leucine derivative.

target

cathepsins B

E-64C(76684-89-4)Related Product Information

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