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E-64C

Basic information Safety Supplier Related

E-64C Basic information

Product Name:
E-64C
Synonyms:
  • (2S,3S)-TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-3-METHYLBUTANE
  • (2S,3S)-L-TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-3-METHYLBUTANE
  • (2S,3S)-3-(((S)-1-(isopentylaMino)-4-Methyl-1-oxopentan-2-yl)carbaMoyl)oxirane-2-carboxylic acid
  • 2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,(2S,3S)-
  • Loxistatin Acid (E-64C)
  • NSC 694279
  • E-64c, EP 475
  • (1S,2S)-2-(((S)-1-(Isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)cyclopropanecarboxylic
CAS:
76684-89-4
MF:
C15H26N2O5
MW:
314.38
Product Categories:
  • Pepetides
  • Inhibitors
  • peptides
Mol File:
76684-89-4.mol
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E-64C Chemical Properties

storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
≥31.4 mg/mL in DMSO; insoluble in H2O; ≥111.8 mg/mL in EtOH
form 
White to off-white solid
color 
White to off-white
InChIKey
SCMSYZJDIQPSDI-SRVKXCTJSA-N
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Safety Information

WGK Germany 
3
RTECS 
RR0404200
HS Code 
29241990

MSDS

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E-64C Usage And Synthesis

Description

E-64c is an active metabolite of the protease inhibitor E-64d . E-64c inhibits the cysteine proteases cathepsin B, cathepsin H, and papain but not the serine proteases trypsin, chymotrypsin, or elastase. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease when used at concentrations ranging from 0.1 to 1 mg/ml. E-64c reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) surface glycoprotein, also known as the spike glycoprotein, in a concentration-dependent manner.

Uses

E-64c is a cysteine protease inhibitor used for detecting autophagy in plants.

Definition

ChEBI: E-64c is a leucine derivative.

target

cathepsins B

E-64CSupplier

DKMbiochem.Co. Ltd Gold
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15901859516
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Alabiochem Tech.Co., Ltd.
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512-58900862 400-0707518
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277
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marketing_china@spectrumchemical.com