2H-1,2,3 TRIAZOLE-2-ACETIC ACID Chemical Properties

Boiling point:

344.0±44.0 °C(Predicted)

Density 

1.53±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

2?+-.0.10(Predicted)

Appearance

Off-white to light yellow Solid

2H-1,2,3 TRIAZOLE-2-ACETIC ACID Usage And Synthesis

Synthesis

The general procedure for the synthesis of 2H-2-acetic acid-1,2,3-triazole-1,2,3-triazole from ethyl 2-(2H-1,2,3-triazol-2-yl)acetate was as follows: 1. Preparation of 2H-1,2,3-triazol-2-ylacetic acid: a solution of lithium hydroxide monohydrate (2.5 g, 60 mmol) in water (15 mL) was added to a solution of ethyl 2-(2H-1,2,3-triazol-2-yl)acetate (7.8 g, 50 mmol), and the reaction was stirred for 18 h at room temperature. 2. Upon completion of the reaction, the reaction mixture was acidified with 2M hydrochloric acid (150 mL) followed by extraction with dichloromethane (150 mL x 3). 3. The organic phases were combined, dried over magnesium sulfate and concentrated under reduced pressure to afford 2H-2-acetic acid-1,2,3-triazole as a white solid in 81% (5.2 g) yield. 4. 4. Product characterization: 1H NMR (400 MHz, CDCl3) δ: 5.35 (s, 2H), 7.72 (s, 2H); LRMS APCI m/z 128 [M + H]+.

References

[1] Patent: WO2006/123242, 2006, A1. Location in patent: Page/Page column 35

2H-1,2,3 TRIAZOLE-2-ACETIC ACID(4320-91-6)Related Product Information

• Vinyl acetate
• Halcinonide
• 1H-1,2,4-TRIAZOLE-1-ACETIC ACID
• 5-Methyl-1H-1,2,4-triazole-3-acetic acid ethyl ester
• 2-CARBOXYMETHYL-2H-BENZOTRIAZOLE
• 2H-1,2,3 TRIAZOLE-2-ACETIC ACID
• 1H-1,2,3 TRIAZOLE-1-ACETIC ACID
• 2H-1,2,3 TRIAZOLE-2-ACETIC ACID ETHYL ESTER
• 1H-1,2,4-TRIAZOLE-1-ACETIC ACID,1,2,4-TRIAZOLE-1-ACETIC ACID
• 1H-1,2,3-TRIAZOLE-1-ACETIC ACID ETHYL ESTER
• 4H-1,2,4-Triazole-4-acetic acid, 3-methyl-, hydrazide
• 3-AMINO-1,2,4-TRIAZOLE-5-ACETIC ACID
• 1H-1,2,3 TRIAZOLE-1- ACETIC ACID HYDROCHLORIDE
• 1H-1,2,4-Triazole-1-acetic acid, -alpha--methyl-, hydrazide
• 1,2,3-Triazole-1-acetic acid, 5-hydroxy-, hydrazide (1CI)
• SPECS AO-245/25054002
• 2-BENZOTRIAZOL-2-YL-PROPIONIC ACID