J104129 Chemical Properties

storage temp. 

2-8°C

solubility 

Soluble to 100 mM in DMSO and to 50 mM in ethanol

form 

powder

color 

white to beige

optical activity

[α]/D -6 to -8°, c = 1 in methanol

J104129 Usage And Synthesis

Uses

J 104129 Fumarate is a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors.

Biochem/physiol Actions

J104129 is a muscarinic M3 receptor antagonist greater than 100-fold selectivity for M3 over M2 receptors. Its Ki for M3 receptors = 4.2 nM compared to a Ki of 490 nM for M2 receptors. J-104129 showed potent bronchodilator activity in animal studies.

storage

Store at +4°C