dBET6
dBET6 Basic information
- Product Name:
- dBET6
- Synonyms:
-
- dBET6
- DBET6;DBET-6 ;DBET 6
- (6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
- 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)-
- 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)acetamide
- dBET-6,Apoptosis,PROTACs,Inhibitor,inhibit,dBET6,Epigenetic Reader Domain,dBET 6
- 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02?]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[8-[[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetyl]amino]octyl]acetamide
- dBET6, 10 mM in DMSO
- CAS:
- 1950634-92-0
- MF:
- C42H45ClN8O7S
- MW:
- 841.37
- Mol File:
- 1950634-92-0.mol
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dBET6 Chemical Properties
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:60.0(Max Conc. mg/mL);71.32(Max Conc. mM)
Ethanol:35.0(Max Conc. mg/mL);41.6(Max Conc. mM) - form
- A solid
- pka
- 10.68±0.40(Predicted)
- color
- White to light yellow
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dBET6 Usage And Synthesis
Description
dBET6 is a potent, selective, and cell-permeable PROTAC connected by ligands for Cereblon and BET and has antitumor activity.
Definition
ChEBI: DBET6 is an organic molecular entity.
Biological Activity
dBET6 is a BET bromodomains PROTAC degrader with good cell permeability, binding to BRD4 with an IC50 of 14 nM. It also induces down-regulation and apoptosis of c-MYC.
target
| Target | Value |
| BRD4 () | 14 nM |
storage
Store at -20°C
dBET6Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
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- 021-61350663 13052117465
- sales@zehanbiopharma.com
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
- info@efebio.com
ShangHai Biochempartner Co.,Ltd
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- 17754423994 17754423994
- 2853530910@QQ.com
Shanghai Rechem science Co., Ltd.
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- 21-31433387 15618786686
- sales@rechemscience.com