Basic information Safety Supplier Related

VL285

Basic information Safety Supplier Related

VL285 Basic information

Product Name:
VL285
Synonyms:
  • VL285
  • VL-285; VL 285; VL285
  • 2-Pyrrolidinecarboxamide, 1-[(2S)-2-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-3-methyl-1-oxobutyl]-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (2S,4R)-
  • (2S,4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-1-[(2S)-3-methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoyl]pyrrolidine-2-carboxamide
  • (2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
  • E3 ligase-recruiting Moiety,VL-285,Ligands for E3 Ligase,Inhibitor,inhibit,VL285,VL 285
  • VL285, 10 mM in DMSO
CAS:
1448188-57-5
MF:
C29H32N4O4S
MW:
532.65
Mol File:
1448188-57-5.mol
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VL285 Chemical Properties

storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
form 
Solid
color 
White to off-white
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VL285 Usage And Synthesis

Uses

VL285 is a potent VHL ligand with an IC50 of 0.34 μM[1].

IC 50

VHL

References

[1] Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. DOI:10.1021/acschembio.5b00442

VL285Supplier

Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Email
info@chemlin.com.cn
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Email
product02@bidepharm.com
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com