FD-1080
FD-1080 Basic information
- Product Name:
- FD-1080
- Synonyms:
-
- FD-1080
- Heptamethine cyanine dye FD 1080
- Heptamethine cyanine dye FD1080
- Heptamethine cyanine dye FD-1080
- Sodium 4-(2-(2-(2-chloro-3-(2-(1-(4-sulfonatobutyl)benzo[cd]indol-1-ium-2-yl)vinyl)cyclohex-2-en-1-ylidene)ethylidene)benzo[cd]indol-1(2H)-yl)butane-1-sulfonate
- FD-1080(Sodium)
- CAS:
- 1151666-58-8
- MF:
- C40H40ClN2NaO6S2
- MW:
- 767.33
- Mol File:
- 1151666-58-8.mol
FD-1080 Usage And Synthesis
Biological Activity
FD-1080 is a fluorophore with excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm) for in vivo imaging.
in vitro
FD-1080 shows superior photostability under the continuous laser irradiation. The quantum yield of FD-1080 is 0.31%, and can be increased to 5.94% after combining with fetal bovine serum (FBS) to form FD-1080 -FBS complexes.
in vivo
The 1064 nm NIR-II excitation of FD-1080 is demonstrated with the high tissue penetration depth and superior imaging resolution compared to NIR excitation from 650 nm to 980 nm. Deeptissue and high-resolution in vivo imaging for the left hindlimb vasculature, abdomen, and brain vessels were realized, allowing penetration through intact skin, tissue, and skull. It also quantifies the respiratory rate based on the dynamic imaging of respiratory craniocaudal motion of the liver for the awake and anaesthetized mouse.
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