Prednisone Impurity 13
Prednisone Impurity 13 Basic information
- Product Name:
- Prednisone Impurity 13
- Synonyms:
-
- Prednisone Impurity 13
- 9α-bromo-11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate
- BNKY015-BD02
- (11β,16α)-21-(Acetyloxy)-9-bromo-11,16,17-trihydroxy-pregna-1,4-diene-3,20-dione
- Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-bromo-11,16,17-trihydroxy-, (11β,16α)-
- 9α-bromo-11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate
- Prednisone Impurity 5
- Budesonide Impurity 53
- CAS:
- 91160-89-3
- MF:
- C23H29BrO7
- MW:
- 497.38
- Mol File:
- 91160-89-3.mol
Prednisone Impurity 13 Chemical Properties
- Boiling point:
- 636.3±55.0 °C(Predicted)
- Density
- 1.53±0.1 g/cm3(Predicted)
- pka
- 11.57±0.70(Predicted)
Prednisone Impurity 13 Usage And Synthesis
Uses
(11β,16α)-21-(Acetyloxy)-9-bromo-11,16,17-trihydroxy-pregna-1,4-diene-3,20-dione is used as a reactant in the synthesis of triamcinolone acetonide, a synthetic corticosteroid used to treat skin conditions.
Synthesis
50.5 g of 2-((8S,10S,13S,14S,16R,17S)-16,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate was dissolved in 1500 ml of acetone, 70 ml of 5% perchloric acid was added, the temperature was lowered to 0°C with stirring, and 45 g of N-bromosuccinimide was added and stirred After the reaction was completed, 50 ml of 20% sodium sulfite aqueous solution was added, the acetone was concentrated, the water was separated, filtered, and dried to obtain 62 g of Prednisone Impurity 13 (9α-bromo-11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate).
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