1-Pyrenebutyric acid-PEG2-azide Usage And Synthesis

Uses

Pyrene azide 3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Pyrene azide 3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014. DOI:10.1016/j.chembiol.2020.07.020

1-Pyrenebutyric acid-PEG2-azide(2252168-06-0)Related Product Information

• PEP azide
• PYRENE-1-SULFONIC ACID SODIUM SALT