DIMETHYL 4-HYDROXYPHTHALATE Chemical Properties

Melting point:

110-111℃

Boiling point:

330.6±22.0℃ (760 Torr)

Density 

1.284±0.06 g/cm3 (20 ºC 760 Torr)

Flash point:

129.3±15.8℃

storage temp. 

Sealed in dry,Room Temperature

pka

7.54±0.18(Predicted)

Appearance

Off-white to light yellow Solid

DIMETHYL 4-HYDROXYPHTHALATE Usage And Synthesis

Chemical Properties

white solid

Synthesis Reference(s)

Tetrahedron Letters, 18, p. 611, 1977 DOI: 10.1016/S0040-4039(01)92706-6

Synthesis

General procedure for the synthesis of dimethyl 4-hydroxyphthalate from methanol and 4-hydroxyphthalic acid: 1. thionyl chloride (20 mL) was slowly added to a methanol (100 mL) solution of 4-hydroxyphthalic acid (20 g, 110 mmol). 2. The reaction mixture was stirred at 0 °C, then warmed to 80 °C and held for 4 hours. 3. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure to give dimethyl 4-hydroxyphthalate (C1-2) as a white solid (23 g, yield: 99%), which could be used in the next step without further purification. 4. 4. The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz) and mass spectrometry (ESI): 1H NMR δ 7.77 (d, J = 8.8 Hz, 1H), 7.03 (d, J = 2 Hz, 1H), 6.95 (dd, J = 8.4 and 2.0 Hz, 1H), 3.93 (s, 3H), 3.88 (s, 3H); MS ( ESI) m/z 211 ([M+H]+).

References

[1] Patent: WO2014/18866, 2014, A1. Location in patent: Paragraph 00175; 00176
[2] ChemMedChem, 2010, vol. 5, # 2, p. 213 - 231
[3] Chemistry of Materials, 2014, vol. 26, # 14, p. 4151 - 4162
[4] Patent: US2015/56305, 2015, A1. Location in patent: Paragraph 0270; 0271; 0387; 0388
[5] Chemical Science, 2018, vol. 9, # 24, p. 5312 - 5321

DIMETHYL 4-HYDROXYPHTHALATE(22479-95-4)Related Product Information

• Phthalic acid
• Dimethyl phthalate
• 4-Hydroxyphthalic acid
• 4-HYDROXYPHTHALIC ACID DIMETHYL ESTER = DIMETHYL-4-HYDROXYPHTHALATE
• DIMETHYL 4-METHOXYBENZENE-1,2-DICARBOXYLATE
• RARECHEM AL BI 0846
• AKOS 227-90
• RARECHEM AL BF 0846
• AKOS 227-89
• AKOS 218-16
• DIMETHYL 4-HYDROXYPHTHALATE
• AKOS 227-94