ELA-11 (human) Chemical Properties

Density 

1.47±0.1 g/cm3(Predicted)

form 

Solid

pka

3.43±0.20(Predicted)

color 

White to off-white

Sequence

Cys-Met-Pro-Leu-His-Ser-Arg-Val-Pro-Phe-Pro

ELA-11 (human) Usage And Synthesis

Uses

ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment[1].

References

[1] Yang P, et, al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135(12):1160-1173. DOI:10.1161/CIRCULATIONAHA.116.023218