Glycine-15N
Glycine-15N Basic information
- Product Name:
- Glycine-15N
- Synonyms:
-
- GLYCINE-(15)N, 98 (ATOM % (15)N)
- GLYCINE-15N, 99 ATOM % 15N
- 2-azanylacetic acid
- 2-azanylethanoic acid
- Glycine-15N
- [15N]Glycine
- Glycine labeled with nitrogen-15
- Nitrogen-15 glycine
- CAS:
- 7299-33-4
- MF:
- C2H5NO2
- MW:
- 76.08
- Product Categories:
-
- Glycine
- Peptide Synthesis
- Amino Acids 13C, 2H, 15N
- G-H
- Metabolic Research
- G-HPeptide Synthesis
- GlycineMass Spectrometry
- Products for SILACMore...Close...
- Alphabetical Listings
- Amino Acid Derivatives
- Amino Acids
- Amino Acids and DerivativesStable Isotopes
- Amino AcidsStable Isotopes
- Biomolecular MS
- Biomolecular NMR
- Labeled Amino AcidsStable Isotopes
- Proteomics Stable Isotope Labeling
- Stable Isotopes
- Mol File:
- 7299-33-4.mol
Glycine-15N Chemical Properties
- Melting point:
- 240 °C (dec.)(lit.)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Aqueous Base (Slightly, Sonicated, Heated), Water (Sparingly)
- form
- Solid
- color
- White to Off-White
- BRN
- 1853034
- InChIKey
- DHMQDGOQFOQNFH-LBPDFUHNSA-N
- CAS Number Unlabeled
- 56-40-6
- CAS Number Unlabeled
- 56-40-6
MSDS
- Language:English Provider:SigmaAldrich
Glycine-15N Usage And Synthesis
Chemical Properties
White powder
Uses
Glycine-15N is the labelled form of Glycine (G615990). Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Biological Activity
Glycine-15N is the 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[1].
IC 50
NMDA Receptor
References
[1] EDWARD M RUSSAK Edward M B. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals.[J]. Annals of Pharmacotherapy, 2019, 53 2: 211-216. DOI:10.1177/1060028018797110.
[2] W. GREENAWAY F. R W. A convenient synthesis of creatine-15N from glycine-15N via sarcosine-15N[J]. Journal of labelled compounds & radiopharmaceuticals, 1978, 14 4: 611-615. DOI:10.1002/jlcr.2580140417.
[3] HE J, ZHANG X, HE Q, et al. Synthesis of 15N-labeled heterocycles via the cleavage of C–N bonds of anilines and glycine-15N†[J]. Chemical Communications, 2021, 44: 5442-5445. DOI:10.1039/D1CC01734A.
[4] T P STEIN. Measurement of protein synthesis rates with [15N]glycine.[J]. American Journal of Physiology, 1980, 239 4: E294-E300. DOI:10.1152/ajpendo.1980.239.4.E294.
[5] MOSTAFA OTHMAN. Millimeter-Sized Clusters of Triple Cation Perovskite Enables Highly Efficient and Reproducible Roll-to-Roll Fabricated Inverted Perovskite Solar Cells[J]. Advanced Functional Materials, 2021, 32 12. DOI:10.1002/adfm.202110700.
Glycine-15NSupplier
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Glycine-15N(7299-33-4)Related Product Information
- H-[15N]ALA-OH
- L-ASPARATIC ACID-15N
- H-[15N]LEU-OH
- N-(9-FLUORENYLMETHOXYCARBONYL)GLYCINE-1-13C-15N
- Glycine-15N
- GLYCINE-1-13C-15N
- DL-ASPARTIC-2-13C-15N ACID
- DL-PHENYLALANINE-15N
- L-GLUTAMINE (ALPHA-15N)
- L-ASPARAGINE-15N2
- GLYCINE-2-13C-15N
- N-(TERT-BUTOXYCARBONYL)GLYCINE-15N, 99 A TOM % 15N,N-(TERT-BUTOXYCARBONYL)GLYCINE-15N,N-(tert-Butoxycarbonyl)glycine-15N, Glycine-15N, N-t-Boc derivative
- GLYCINE (U-13C2, 15N)
- DIETHYL ACETAMIDOMALONATE-15N
- L-GLUTAMIC-15N ACID
- H-[15N]TYR-OH
- DL-4-HYDROXYPHENYLALANINE-15N
- DL-ALANINE-15N