1 2 3 4-TETRAHYDROCYCLOPENT(B) INDOLE Chemical Properties

Melting point:

100.5-105.5 °C(lit.)

Boiling point:

160-162 °C(Press: 1 Torr)

Density 

1.200±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Chloroform, Methanol

form 

powder to crystaline

pka

17.83±0.20(Predicted)

color 

Light yellow to Brown

λmax

230nm(EtOH aq.)(lit.)

InChI

1S/C11H11N/c1-2-6-10-8(4-1)9-5-3-7-11(9)12-10/h1-2,4,6,12H,3,5,7H2

InChIKey

HZDXFZHFEASSBM-UHFFFAOYSA-N

SMILES

C1Cc2[nH]c3ccccc3c2C1

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2933.99.9701

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

1 2 3 4-TETRAHYDROCYCLOPENT(B) INDOLE Usage And Synthesis

Uses

• ;Reactant for thionium species-mediated functionalization at the 2α-position of indoles1• ;Reactant for preparation of tetramethylpiperidine-1-oxoammonium salts as oxidants2

Uses

1,2,3,4-Tetrahydrocyclopent[b]indole is used in the synthesis of BACE inhibitors. Also used to synthesize benzazocinecarboxylic acids as potential antiinflammatory agents.

Uses

• Reactant for thionium species-mediated functionalization at the 2α-position of indoles
• Reactant for preparation of tetramethylpiperidine-1-oxoammonium salts as oxidants

General Description

1,2,3,4-Tetrahydrocyclopent[b] indole undergoes reduction in the presence of Pd/C and hydrogen gas to yield 1,2,3,3a,4,8b-hexahydrocyclopent[b]indole.

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