TAUTOMYCETIN SOLUTION
TAUTOMYCETIN SOLUTION Basic information
- Product Name:
- TAUTOMYCETIN SOLUTION
- Synonyms:
-
- (1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester
- TAUTOMYCETIN SOLUTION
- 3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-furan-3-yl)propionic acid 16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxooctadeca-15,17-dienyl ester solution
- (1R*,2S*)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoicacidester
- 3-Furanpropanoic acid, 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-, (1R,2S,6S,7S,10S,12R,15E)-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadien-1-yl ester, (βR)-
- Tautomycetin (10mg/mL in DMSO) DISCONTINUED
- CAS:
- 119757-73-2
- MF:
- C33H50O10
- MW:
- 606.75
- Mol File:
- 119757-73-2.mol
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TAUTOMYCETIN SOLUTION Chemical Properties
- Boiling point:
- 763.7±60.0 °C(Predicted)
- Density
- 1.148±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 10 mg/mL
- form
- Colourless liquid
- pka
- 12.36±0.20(Predicted)
- color
- colorless
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TAUTOMYCETIN SOLUTION Usage And Synthesis
Uses
Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. Tautomycin is closely related to another anhydride containing polyketide PP inhibitor called Tautomycetin which, in addition to being useful as a lead for cancer drug discovery, also is a very potent immunosuppressor.
Definition
ChEBI: Tautomycetin is a sesquiterpenoid.
Biological Activity
Potent activated T cell-specific immunosuppressor. Selectively inhibits PP1 over PP2 with IC 50 values of 1.6 and 62 nM respectively. Active in vivo .
TAUTOMYCETIN SOLUTIONSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
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Shanghai Witofly Chemical Co.,Ltd
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- sales@witofly.com
TargetMol Chemicals Inc.
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- +1-781-999-5354 +1-00000000000
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Energy Chemical
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MedBioPharmaceutical Technology Inc
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