2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine Chemical Properties

Boiling point:

629.7±65.0 °C(Predicted)

Density 

1.77±0.1 g/cm3(Predicted)

pka

13.05±0.70(Predicted)

2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine Usage And Synthesis

Uses

2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

References

[1] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020
[2] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005